Researchers revealed that abnormal delivery of zinc to lung cells contributes to obstructive pulmonary diseases. They further showed that mRNA splicing abnormalities are involved in the detailed mechanism. So far, the importance of zinc in the lung has only been understood from a nutritional aspect. This discovery is thought to be the first to clarify zinc's effects on the regulation of mRNA ligation (splicing), and its involvement in the onset of pulmonary diseases.
The natural decline in lung function over a 10-year period was slower among former smokers with a diet high in tomatoes and fruits, especially apples, suggesting certain components in these foods might help restore lung damage caused by smoking.
Does a stay in the intensive care unit give patients a better chance of surviving a chronic obstructive pulmonary disease (COPD) or heart failure flare-up or even a heart attack, compared with care in another type of hospital unit? Unless a patient is clearly critically ill, the answer may be no, according to researchers who analyzed more than 1.5 million Medicare records.
Premature babies that need ventilation to support their breathing often suffer from a condition known as bronchopulmonary dysplasia. Researchers have now discovered a molecular mechanism that plays a key role in the development of the disease.
Increased arterial stiffness is a known predictor of cardiovascular diseases in different populations, including healthy subjects and patients with hypertension, diabetes, or renal disease. A new study examining arterial stiffness in a large population determined that both restrictive spirometry pattern and reduced forced vital capacity (FVC) were associated with a higher risk of arterial stiffness not only in men but also in women. The investigators found that arterial stiffness increased fourfold when FVC decreased.
Researchers describe how the concentration of mucins -- the proteins that make mucus thick -- is abnormally high in chronic bronchitis and that high mucin concentrations are associated with disease severity in people with chronic bronchitis. This finding could become the first-ever objective marker of chronic bronchitis and lead to the creation of diagnostic and prognostic tools.